Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells
Year: 2020
Type: article
Abstract: Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in their proliferative activity, partly related to changes in the systemic environment. Here we report the identification of CCN4/Wisp1 as a circulating factor more abundant in pre-weaning than in adult mice. We show that Wisp1 promotes endogenous and transplanted adult beta cell proliferation in vivo. We validate these findings using isolated mouse and human islets and find that the beta cell trophic effect of Wisp1 is dependent on Akt signaling. In summary, our study reveals the role of Wisp1 as an inducer of beta cell replication, supporting the idea that the use of young blood factors may be a useful strategy to expand adult beta cell mass.
Source: Nature Communications
Institutions: Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Hôpital Saint Eloi, Centre Hospitalier Universitaire Vaudois, National Institutes of Health, National Institute of Dental and Craniofacial Research, Hospital Clínic de Barcelona, Universitat Oberta de Catalunya, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,380
Funders: Generalitat de Catalunya, Ministerio de Economía y Competitividad, Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas, National Institutes of Health, Instituto de Salud Carlos III, European Regional Development Fund, National Institute of Dental and Craniofacial Research
Awards: Mecanismos reguladores de la proliferación de la célula beta pancreática en el diseño de nuevas estrategias terapéuticas en diabetes, G1075404386, G2099099426, G2898190619, FIBROBLASTOS HUMANOS COMO FUENTE DE CÉLULAS PRODUCTORAS DE INSULINA, PROLIFERACIÓN DE LA CÉLULA ß PANCREÁTICA: IMPACTO DE NUEVOS REGULADORES, G4836111256, G518169470, G6078603271, G7616772132
OpenAlex ID: W3108133179