Work

Merging Pediatric Index of Mortality (a physiologic instability measure), lactate, and Systemic Inflammation Mortality Risk to better predict outcome in pediatric sepsis

Year: 2020

Type: article

Abstract: One in five deaths occur globally as a result of sepsis, with the majority occurring in newborns and children in resourcepoor settings.1 Whereas public health efforts in Brazil have reduced pediatric deaths from sepsis by 75%, mortality in hospitalized children remains stubbornly high at above 20%, particularly in the São Paulo region. 2 In today's journal, Tonial et al. report the first attempt at merging PIM2, a measure of physiologic instability, with lactate, and Systemic Inflammation Mortality Risk in order to better predict mortality in pediatric sepsis.3 They found that the Youden's J test best cut-off value PIM2 score has an accuracy (true positives + true negatives/all tests) of 0.880, which increases to 0.945 with the addition of the best Youden's test cutoffs for lactate plus the two components of Systemic Inflammation Mortality Risk, namely C-reactive protein and ferritin, in predicting pediatric sepsis mortality in their PICU.The PIM2, PRISM IV, TOPICC, PEMOD, and PELOD-2 scores are among the most commonly used measures of physiological instability and organ dysfunction-related mortality risk in pediatric intensive care.Over the years, the PIM2, PRISM IV, and TOPICC scores have added high-risk and lowrisk diagnoses to further improve their ability to predict

Source: Jornal de Pediatria

DOI: 10.1016/j.jped.2020.11.001

Authors: Christopher M. Horvat, Dennis W. Simon, Zachary Aldewereld, Idris Evans, Rajesh Aneja, Joseph A. Carcillo

Institutions: Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, UPMC Health System

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800