Work

Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer

Year: 2020

Type: preprint

Abstract: Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk between metabolism and EMT, but how this leads to coordinated physiological changes is still uncertain. The elusive connection between metabolism and EMT compromises the efficacy of metabolic therapies targeting metastasis. In this review, we aim for clarifying causation between metabolism and EMT based on recent experimental studies and propose integrated theoretical-experimental efforts to better understand the coupled decision-making of metabolism and EMT.

Source: arXiv (Cornell University)

DOI: 10.48550/arxiv.2011.13554

Authors: Jia, Dongya, Park, Jun Hyoung, Kaur, Harsimran, Jung, Kwang Hwa, Yang, Sukjin, Tripathi, Shubham, Galbraith, Madeline, Deng, Youyuan, Jolly, Mohit Kumar, Kaipparettu, Benny Abraham, Onuchic, Jose N., Levine, Herbert

Institutions: Center for Theoretical Biological Physics, Rice University, Baylor College of Medicine, Indian Institute of Science Bangalore, Dan L Duncan Comprehensive Cancer Center

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, U.S. Department of Defense, Cancer Prevention and Research Institute of Texas, National Institutes of Health, Science and Engineering Research Board

Awards: G1464847639, G227903998, The energy landscape for folding and function of biomolecules: integrating physical models, genetic information and experiments, G4119534169, G4662977423, G500871726, G5850682332, Center for Theoretical Biological Physics, Computational Cancer Biology Training Program, Graduate Research Fellowship Program(GRFP), G7164944932, Spatial Patterning in the Progressing Tumor - The Role of Notch, G8166743225, Collaborative Research: PoLS Student Research Network, G9000129960, G9000254165

OpenAlex ID: W3108772012

Cites: 90

Cited by: 3

Related to: 10