Work

The ubiquitylome of developing cortical neurons

Year: 2020

Type: article

Abstract: Ubiquitylation is a posttranslational protein modification, in which the small protein ubiquitin is covalently attached to substrate proteins. This modification can mark substrates for degradation by the proteasome or lysosomes, or alternatively can alter protein localization, function, trafficking, and protein-protein interactions. Ubiquitylation is a ubiquitous modification, but it is enriched in the brain and often accumulates in neurodegenerative conditions (Fischer et al., 2009).

Source: PubMed

DOI: 10.17912/micropub.biology.000333

Authors: Shalini Menon, Dennis Goldfarb, Emily M. Cousins, M. Ben Major, Stephanie L. Gupton

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Mental Health, National Institute of General Medical Sciences