Work

Cancer Immunoediting in Gliomas: Recent Advances and Implications for Immunotherapy

Year: 2020

Type: article

Abstract: Gliomas are an aggressive class of primary brain tumors with high rates of recurrence and a dismal overall survival. While existing therapeutic strategies provide some benefit, their effects are variable, and no curative modalities exist. The poor prognosis of these patients largely stems from the heterogenous molecular profile of these tumors and their tumor immune microenvironment (TIME). In addition to tumor expression of PD-L1, glioma cells release immunosuppressive cytokines and chemokines, like IL-10, TGF-?, and PGE2 in the intercellular tumor milieu, which have been shown to reduce antigen presenting activity and downregulate the proliferation of natural killer (NK) and CD8+ cytotoxic T-cells

Source: Journal of Cellular Immunology

DOI: 10.33696/immunology.2.066

Authors: Parth V. Shah, Víctor A. Arrieta, Catalina Lee-Chang, Adam M Sonabend

Institutions: Northwestern University, Universidad Nacional Autónoma de México

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke