Maternal GDM Status, Genetically Determined Blood Glucose, and Offspring Obesity Risk: An Observational Study
Year: 2020
Type: article
Study design: Observational Study
Abstract: Objective The purpose of this study was to estimate the associations of genetically determined maternal blood glucose levels with obesity‐related outcomes among children from pregnancies with and without gestational diabetes mellitus (GDM). Methods A total of 1,114 mothers with (N = 560) and without (N = 554) GDM and their children were included in the present study. A maternal genetic risk score (GRS) for blood glucose was constructed on the basis of 17 single‐nucleotide polymorphisms identified from a recent genome‐wide association study. Results It was found that maternal GRS for blood glucose showed different associations with offspring risk of overweight and obesity, as well as adiposity measures (all P for interaction < 0.05). Among mothers without GDM, genetically determined maternal blood glucose levels were associated with an 89% higher risk of overweight in their children (95% CI: 42%‐152% per SD increase in GRS, P = 1.40 × 10−5) and a 120% higher risk of obesity (44%‐235%, P = 2.61 × 10−4) after adjustment for covariates. In addition, higher maternal GRS for blood glucose was associated with children's increased obesity‐related traits (all P < 0.05). However, no significant associations were observed among children of mothers with GDM. Conclusions This study indicates that GDM status may modify the relation between genetically determined glucose levels and obesity risk among children.
Source: Obesity
DOI: 10.1002/oby.23047
Institutions: Tulane University, Peking University, Tianjin Women's and Children's Health Center, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang University, Sichuan University, Tianjin Medical University, Universidade de São Paulo, Pennington Biomedical Research Center, Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Eli Lilly and Company, European Foundation for the Study of Diabetes, China Scholarship Council, Chinese Diabetes Society, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota, Obesity Genes, Energy Regulation in Response to Weight-Loss Diets, G1861573265, Genetic Markers of CHD in Type 2 Diabetes, Dissecting the impact of forced displacement on Type Two Diabetes, G3039652434, G3613299566, G3896680578, G401738796, G430694384, G5511382046, Genome-wide interactions with diet patterns on long-term weight change, G588599347, Methylomics of prenatal GDM: Natural history & lifestyle intervention in children, G6812933845, G7286868595, G8046189488, G8787159316, Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions, Louisiana Clinical and Translational Science Center, RISK FACTORS FOR CVD IN WOMEN, G958196485
OpenAlex ID: W3109535027