Work

100th Anniversary of Macromolecular Science Viewpoint: Degradable Polymers from Radical Ring-Opening Polymerization: Latest Advances, New Directions, and Ongoing Challenges

Year: 2020

Type: editorial

Abstract: Radical ring-opening polymerization (rROP) allows facile incorporation of labile groups (e.g., ester) into the main chain of vinyl polymers to obtain (bio)degradable materials. rROP has focused a lot of attention especially since the advent of reversible deactivation radical polymerization (RDRP) techniques and is still incredibly moving forward, as attested by the numerous achievements in terms of monomer synthesis, macromolecular engineering, and potential biomedical applications of the resulting degradable polymers. In the present Viewpoint, we will cover the latest progress made in rROP in the last ∼5 years, such as its recent directions, its remaining limitations, and the ongoing challenges. More specifically, this will be achieved through the three different classes of monomers that recently caught most of the attention: cyclic ketene acetals (CKA), thionolactones, and macrocyclic monomers.

Source: ACS Macro Letters

DOI: 10.1021/acsmacrolett.0c00676

Authors: Théo Pesenti, Julien Nicolas

Institutions: Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut Galien Paris-Saclay

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Agence Nationale de la Recherche, Centre National de la Recherche Scientifique

Awards: Biodegradable, PEGylating polymers: application to the synthesis of nanoparticles and bioconjugates, Design of a novel class of biodegradable and functionalized polyesters for cardiac application

OpenAlex ID: W3110095379

Cites: 127

Cited by: 215

Related to: 10