Year: 2020
Type: review
Abstract: The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The nurturing vascular niches in the BM are complex and heterogenous consisting of distinct vascular and perivascular cell types that provide crucial signals for the maintenance of stem and progenitor cells. Growing evidence suggests that the BM niche is highly sensitive to stress. Aging, inflammation and other stress factors induce changes in BM niche cells and their crosstalk with tissue cells leading to perturbed hematopoiesis, bone angiogenesis and bone formation. Defining vascular niche remodeling under stress conditions will improve our understanding of the BM vascular niche and its role in homeostasis and disease. Therefore, this review provides an overview of the current understanding of the BM vascular niches for hematopoietic stem cells and their malfunction during aging, bone loss diseases, arthritis and metastasis.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
Funders: Leuka, UK Research and Innovation, Leukaemia UK, Kennedy Trust for Rheumatology Research, Cancer Research UK, National Institute for Health and Care Research, Royal Society, Office of the Royal Society, Versus Arthritis, Medical Research Council, John Fell Fund, University of Oxford, NIHR Oxford Biomedical Research Centre, H2020 European Research Council
Awards: G1232745702, G134321443, G1553062118, G1579348943, G1784896304, G1827164936, G2605610293, G3220016438, G3347082074, G3698543497, G3892411583, G4204163260, G6098300621, Centre for Osteoarthritis Pathogenesis Arthritis UK, G6826288163, G6827572655, G7014893875, G772248917, The functional role and therapeutic potential of vascular niches in bone, Regulation of bone metastases by age-associated angiocrine signals
OpenAlex ID: W3110099477