Work

Preleukemic and leukemic evolution at the stem cell level

Year: 2020

Type: review

Abstract: Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and relapse. We highlight recent advances and unanswered questions about the contribution of the hematopoietic stem cell population to these processes.

Source: Blood

DOI: 10.1182/blood.2019004397

Authors: Jacob Stauber, John M. Greally, Ulrich Steidl

Institution: Albert Einstein College of Medicine

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Cancer Institute, National Institute of General Medical Sciences