Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Year: 2020
Type: article
Study design: Observational Study
Abstract: Background There is accumulating evidence linking prolonged sedentary time to adverse health outcomes. The effect of sedentary behavior on kidney function has not been evaluated in US Hispanics/Latinos, a population disproportionately affected by CKD. Methods We evaluated the association between accelerometer-measured (1 week) sedentary time at baseline and kidney function among 7134 adults without CKD at entry in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), who completed a baseline visit with accelerometry (2008–2011) and a follow-up visit (2014–2017). Outcomes included: ( 1 ) change in kidney function (eGFR and urine albumin-to-creatinine ratio, ACR), ( 2 ) incident low eGFR (eGFR <60 ml/min per 1.73 m 2 and eGFR decline ≥1 ml/min per year), and ( 3 ) incident albuminuria (ACR ≥17 mg/g in men or ≥25 mg/g in women). Linear regression using survey procedures was used to evaluate change in kidney function (eGFR and ACR), and Poisson regression with robust variance was used to evaluate incident low eGFR and albuminuria. Results The median sedentary time was 12 hours/d. Over a median follow-up of 6.1 years, the mean relative change in eGFR was −0.50% per year, and there were 167 incident low eGFR events. On multivariable analysis, each 1 hour increase in sedentary time was associated with a longitudinal decline in eGFR (−0.06% per year, 95% CI, −0.10 to −0.02). There was a significant interaction with sex, and on stratified analyses, higher sedentary time was associated with eGFR decline in women but not men. There was no association between sedentary time and the other outcomes. Conclusions Sedentary time was associated with a small longitudinal decline in eGFR, which could have important implications in a population that experiences a disproportionate burden of CKD but further investigation is needed.
Source: Kidney360
Language: English
Topic: Physical Activity and Health
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Office of Dietary Supplements, Robert Wood Johnson Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: G1121130830, G122677224, G1349668216, Hispanic Community Health Study, G1666450717, G1818487580, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, Sleep-Disordered Breathing and Outcomes in Chronic Kidney Disease, G2970637568, Hispanic Community Health Study, G4143790175, Hispanic Community Health Study, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G6075306088, G6088185517, Health Disparities in Chronic Kidney Disease Mentoring Program, Precision Lifestyle Medicine and Translation Research (PREMIER)
OpenAlex ID: W3110803228