Work

The biogenesis and roles of extrachromosomal oncogene involved in carcinogenesis and evolution.

Year: 2020

Type: review

Abstract: More and more extrachromosomal DNA (ecDNA) was found in human tumor cells in recent years, which has a high copy number in tumors and changes the expression of oncogenes, thus different from normal chromosomal DNA. These circular structures were identified to originate from chromosomes, and play critical roles in rapid carcinogenesis, tumor evolution and multidrug resistance. Therefore, this review mostly focuses on the biogenesis and regulation of extrachromosomal oncogene in ecDNA as well as its function and mechanism in tumors, which are of great significance for our comprehensive understanding of the role of ecDNA in tumor carcinogenic mechanism and are expected to provide ecDNA with the potential to be a new molecular target for the diagnosis and treatment of tumors.

Source: PubMed

Authors: Jianxia Wei, Chunchun Wu, Hanbing Meng, Mengna Li, Weihong Niu, Yuting Zhan, Long Jin, Yumei Duan, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Ming Zhou

Institutions: Central South University, Hunan Cancer Hospital, Second Xiangya Hospital of Central South University

Language: English

Topic: Genomic variations and chromosomal abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3111075030

FWCI: 0.326

Cites: 129

Cited by: 12

Related to: 10