Year: 2020
Type: review
Abstract: Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes to many conditions and can influence disease morbidity and treatment. Diverse approaches used to study endothelial permeability have yielded a wealth of valuable insights. Yet, ongoing questions, technical challenges, and unresolved controversies relating to the mechanisms and relative contributions of barrier regulation, transendothelial sieving, and transport of fluid, solutes, and particulates complicate interpretations in the context of vascular physiology and pathophysiology. Here, we describe recent in vivo findings and other advances in understanding endothelial barrier function with the goal of identifying and reconciling controversies over cellular and molecular processes that regulate the vascular barrier in health and disease.
Source: Trends in Molecular Medicine
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Awards: Angiopoietins in vascular and lymphatic remodeling of airways and lung, G2560009166, G3087913410, G4983169091, ATTRACT: Arterial flow as attractor for endothelial cell migration, G5615028582, Angiopoietin/Tie signaling regulation of vascular leakage in lung inflammation, G6869499818, Mechanisms, consequences, and reversal of abnormalities in lung lymphatics, G8083344115
OpenAlex ID: W3111954174