Work

In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species

Year: 2020

Type: article

Abstract: The Gram-negative bacterial genus Burkholderia includes several hard-to-treat human pathogens: two biothreat species, Burkholderia mallei (causing glanders) and B. pseudomallei (causing melioidosis), and the B. cepacia complex (BCC) and B. gladioli , which cause chronic lung infections in persons with cystic fibrosis. All Burkholderia spp. possess an Ambler class A Pen β-lactamase, which confers resistance to β-lactams.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01930-20

Authors: Krisztina M. Papp-Wallace, Adam B. Shapiro, Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Douglas J. Lane, Rekha G. Panchal, John P. Mueller, John P. O’Donnell, Alita A. Miller

Institutions: VA Northeast Ohio Healthcare System, Case Western Reserve University, Entasis Therapeutics (United States), University of Michigan, Michigan Medicine, United States Army Medical Research Institute of Infectious Diseases

Language: English

Topic: Burkholderia infections and melioidosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Cystic Fibrosis Foundation, Biomedical Laboratory Research and Development, VA Office of Research and Development, Defense Threat Reduction Agency

Awards: G5440579105, G835090404

OpenAlex ID: W3112105013

FWCI: 1.074

Cites: 43

Cited by: 17

Related to: 10