Work

Exploiting Drug Metabolism to Activate Immunity Against Cancer

Year: 2020

Type: article

Abstract: Multidrug resistance is one of the main culprits underlying the failure of chemotherapy as a cancer treatment. Whilst many therapies are initially effective, a considerable proportion of patients eventually incur a poor prognosis and recurrence of malignant spread due to developing drug resistance at a later stage. Dr Rock J. Mancini, from Washington State University, has devised an approach that exploits proteins over-expressed in drug-resistant cancers to convert inactive prodrug substrates into active drugs that initiate an immune response targeted at cancer cells.

DOI: 10.33548/scientia588

Author: Rock J. Mancini

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W3112292612

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