Work

Effect of Non‐Volatile Constituents of Elsholtzia ciliata ( Thunb .) Hyl . from Southern Vietnam on Reactive Oxygen Species and Nitric Oxide Release in Macrophages

Year: 2020

Type: article

Abstract: The extract of Elsholtzia ciliata aerial parts was subjected to bio-guided isolation using the intercellular ROS reduction in J774A.1 macrophages to monitor the anti-oxidative activity. Fifteen compounds were isolated from the active fractions including eleven flavonoids (vitexin, pedalin, luteolin-7-O-β-d-glucopyranoside, apigenin-5-O-β-d-glucopyranoside, apigenin-7-O-β-d-glucopyranoside, chrysoeriol-7-O-β-d-glucopyranoside, 7,3'-dimethoxyluteolin-6-O-β-d-glucopyranoside, luteolin, 5,6,4'-trihydroxy-7,3'-dimethoxyflavone, 5-hydroxy-6,7-dimethoxyflavone (compound 13), 5-hydroxy-7,8-dimethoxyflavone); three hydroxycinnamic acid derivatives (caffeic acid, 4-(E)-caffeoyl-l-threonic acid, 4-O-(E)-p-coumaroyl-l-threonic acid) and one fatty acid (α-linolenic acid). The biological evaluation of these compounds (10-2.5 μm) indicated that all of them exerted good antioxidant and anti-inflammatory activities, in particular compound 13.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202000577

Authors: Dieu T. X. Nguyen, Hung Tran, Stefan Schwaiger, Hermann Stuppner, Stefania Marzocco

Institutions: Universität Innsbruck, University of Medicine and Pharmacy at Ho Chi Minh City, University of Salerno

Language: English

Topic: Phytochemistry and Biological Activities

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,500