Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths
Year: 2020
Type: review
Abstract: Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed.
Source: Molecular Imaging
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,000
Funders: National Science Foundation, Susan G. Komen for the Cure, American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering
Awards: Handheld Wound Analyzer for in situ Healing, G121894090, G1273819419, G1625100665, Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view, G205930180, A turnkey research platform to accelerate clinical translation of focused-ultrasound (FUS) oncology therapies, G2251352131, Development of a Longitudinal Molecular Imaging Platform to Support Immuno-Oncology Research, High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized Organoids, G3972226624, Transcranial Photoacoustic Imaging Using a Virtual Array, Decrypting the Role of Epinephrine on Brain Function after Cardiac Arrest in Mice, CAREER: Optically Programmed Membrane Permeabilization, G6312356580, Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR Light, Whole-organ bioreactor with integrated nondestructive 3D molecular imaging, G8733929058, High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic Stroke, G8825482244, G8960124320
OpenAlex ID: W3112478080