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The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide

Year: 2020

Type: article

Abstract: Passive leg movement (PLM) evokes a highly nitric oxide (NO)-mediated hyperemic response and may provide a novel evaluation of vascular function. The contributions of endothelium-dependent vasodilatory pathways, beyond NO and including prostaglandins and endothelium-derived hyperpolarizing factor, to the PLM-induced hyperemic response to PLM have not been evaluated. With intra-arterial drug infusion, the combined inhibition of nitric oxide synthase (NOS), cyclooxygenase, and cytochrome P-450 (CYP450) pathways did not further diminish the hyperemic response to PLM compared with NOS inhibition alone.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00784.2020

Authors: Joel D. Trinity, Oh Sung Kwon, Ryan M. Broxterman, Jayson R. Gifford, Andrew C. Kithas, Jay R. Hydren, Catherine L. Jarrett, Katherine L. Shields, Angela V. Bisconti, Soung Hun Park, Jesse C. Craig, Ashley D. Nelson, David E. Morgan, Jacob E. Jessop, Amber D. Bledsoe, Russell S. Richardson

Institutions: University of Utah, VA Salt Lake City Healthcare System, University of Connecticut, Brigham Young University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Heart, Lung, and Blood Institute

Awards: G1736160095, G2396695426, Mechanisms of Adaptation to Exercise in Health and COPD, G3608843564, G3682763577, G3958766278, G4125916657, Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse, G7178304349, Cardiovasomobility Research Training Program, G8719066519

OpenAlex ID: W3112924993

FWCI: 1.351

Cites: 67

Cited by: 14

Related to: 10