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Human apolipoprotein A-I and A-II metabolism

Year: 1982
Type: article
Abstract: The kinetics of the major apolipoproteins (apo) of plasma high density lipoproteins (HDL), apoA-I and apoA-11, were examined in a total of 44 individual tracer studies in 22 normal male and female subjects. Following the intravenous injection of radioiodinated HDL, the specific radioactivity decay of apoA-I within HDL (residence time, 5.07 f 1.53 days), as determined by column chromatography, was significantly (P < 0.01) faster than that of apoA-I1 (residence time, 5.96 _t 1.84 days). The specific radioactivity decay of apoA-I within HDL when labeled on HDL or as apoA-I was found to be almost identical. Similar results were obtained for apoA-11. Analysis of simultaneous paired radiolabeled apoA-I and apoA-I1 studies revealed that the mean apoA-I plasma residence time (4.46 k 1.04 days) was significantly (P < 0.01) shorter than that for apoA-I1 (4.97 +- 1.06 days). Females had significantly (P
DOI: 10.1016/s0022-2275(20)38087-1
Authors: E J Schaefer, L A Zech, L L Jenkins, T J Bronzert, E A Rubalcaba, F T Lindgren, R L Aamodt, H B Brewer
Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute, Medical Care Development International, Lawrence Berkeley National Laboratory, National Institutes of Health Clinical Center, University of California, Berkeley
Language: English
Subfield: Biochemistry
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W3113099148
FWCI: 3.036
Cites: 61
Cited by: 206
Related to: 10