Work

Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis

Year: 2020

Type: article

Abstract: BACKGROUND: Post-traumatic stress disorder (PTSD) is a serious stress-related disorder. AIM: To identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods. METHODS: Gene expression profiles were obtained from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified by using GEO2R. Gene functional annotation and pathway enrichment were then conducted. The gene-pathway network was constructed with Cytoscape software. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was applied for validation, and text mining by Coremine Medical was used to confirm the connections among genes and pathways. RESULTS: these pathways, which might serve as key signatures in the pathogenesis of PTSD. CONCLUSION: relevant pathways in PTSD.

Source: World Journal of Psychiatry

DOI: 10.5498/wjp.v10.i12.286