Epstein–Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV
Year: 2021
Type: article
Abstract: Chronic active Epstein Barr Virus (CAEBV) is a rare condition occurring in previously healthy individuals associated with persistent EBV viraemia, fever, lymphadenopathy and hepatosplenomegaly. Viral deletions have been found in CAEBV and other lymphomas. However, it is unclear how stable these deletions are, whether they are present in different sites and how they evolve overtime. We sequenced fourteen longitudinal blood samples from three European CAEBV patients and compared with CAEBV saliva samples and other sequences from EBV-related conditions. We observed large EBV deletions in blood, but not saliva from CAEBV patients. Deletions were stable over time but were lost following successful treatment. Our results are consistent with the likelihood that certain deletions in the virus from CAEBV patients are associated with the evolution and persistence of haematological clones. We propose that the loss of deletions following successful treatment should be investigated as a potential biomarker to aid CAEBV management.
Source: British Journal of Haematology
DOI: 10.1111/bjh.17790
Institutions: University College London, University of Cambridge, Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust, University of Basel, University Hospital of Basel, National Institute for Health and Care Research, NIHR Great Ormond Street Hospital Biomedical Research Centre, Fujita Health University, Imperial College London, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,600
Awards: Functional investigation of Epstein-Barr virus infection and latent gene function using natural variants found in normal infections and cancer cells, G310546029, Development of metagenomics-based diagnostics of infectious diseases, G3230660836, G339059223, Development of metagenomics-based diagnostics of infectious diseases, Analysis of cytomegalovirus pathogenesis in a human challenge system, Analysis of cytomegalovirus pathogenesis in a human challenge system
OpenAlex ID: W3194546467