Work

What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies

Year: 2020

Type: review

Abstract: In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.

Source: Journal of Nuclear Medicine

DOI: 10.2967/jnumed.120.245423

Authors: Victor L. Villemagne, Brian J. Lopresti, Vincent Doré, Dana Tudorascu, Milos D. Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A. Pascoal, N. Scott Mason, Beth Snitz, Howard Aizenstein, Chester A. Mathis, Oscar Lopez, Christopher C. Rowe, William E. Klunk, Ann D. Cohen

Institutions: Edith Cowan University, The University of Melbourne, University of Pittsburgh, Commonwealth Scientific and Industrial Research Organisation, Austin Hospital, CSIRO Health and Biosecurity, Austin Health, Brigham and Women's Hospital, Massachusetts General Hospital

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3113674672

FWCI: 0.573

Cites: 42

Cited by: 35

Related to: 10