Work

Food Allergy: Searching for the Modern Environmental Culprit.

Year: 2020

Type: article

Abstract: Food allergy is a modern disease. Its exponential increase in prevalence in the last 70 years cannot be explained by genetic factors alone. In this review we discuss the hypotheses that have been suggested previously, and the evidence that supports them, to explain this rise in prevalence as well as the medical treatments that have developed as a result of basic exploration within these paradigms. We argue that one major area of fruitful exploration that would help generate new ideas may be systematic analyses of the unknown factors of the modern environment that may contribute to the formation of food allergy. Through this lens, we review the current understanding of food allergy pathogenesis and propose novel research directions, with implications for the current strategies for managing food allergy.

Source: PubMed Central

Authors: Anna S Eisenstein, Brandon Hilliard, Sophia Silwal, Andrew Wang

Institution: Yale University

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Regulation of Metabolic Programs for Host Tolerance to Inflammation, Training in Investigative Dermatology, Yale Clinical and Translational Science Award