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Tumor-infiltrating dendritic cell states are conserved across solid human cancers

Year: 2020
Type: review
Abstract: Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are emerging as an essential antitumor component based on their ability to foster T cell immunity and immunotherapy responses. Here, we discuss our expanding view of DC heterogeneity in human tumors, as revealed with meta-analysis of single-cell transcriptome profiling studies. We further examine tumor-infiltrating DC states that are conserved across patients, cancer types, and species and consider the fundamental and clinical relevance of these findings. Finally, we provide an outlook on research opportunities to further explore mechanisms governing tumor-infiltrating DC behavior and functions.
DOI: 10.1084/jem.20200264
Language: English
Subfield: Immunology
Open Access status: hybrid
Funders: National Science Foundation, Massachusetts General Hospital, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Fondation ISREC, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases
Awards: Single Cell Genome-Wide Myeloid Response Profiling in Immunotherapy, Imaging tumor associated macrophage (TAM) function, In vivo behavior of monocytes in resting and inflammatory conditions, Targeting the tumor endothelium to sensitize lung cancer to immune checkpoint inhibition, Reprogramming PDAC tumor microenvironment to improve immunotherapy, G787762306, Strategies to Overcome Immune Resistance in Head and Neck Cancers
OpenAlex ID: W3113999242
FWCI: 2.75
Cites: 131
Cited by: 240
Related to: 10