Celecoxib Combined with Thalidomide in the Treatment of Refractory Neoplastic Fever in Advanced Cholangiocarcinoma: A Case Report
Year: 2020
Type: article
Study design: Case Report
Abstract: Neoplastic fever, a common symptom of tumors, can be mainly controlled by nonsteroidal antiinflammatories (NSAIDs) and corticosteroids. However, there is no standard treatment guideline for refractory neoplastic fever, which cannot be controlled by the medicines mentioned above. This report presents a case of advanced cholangiocarcinoma with persistent fever lasting 3 weeks. After ineffective treatment with various antibiotics, ibuprofen, and corticosteroids, the body temperature returned to normal after a 48-hour treatment with celecoxib + thalidomide. Finally, the overall survival (OS) of the patient reached 8 months with radiotherapy and chemotherapy.
Source: Journal of Surgical Oncology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3114094007