T FH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function
Year: 2020
Type: article
Abstract: Significance A successful vaccine depends on productive T follicular helper (T FH ) and B-cell responses to elicit protective immunity. Vaccines are delivered as live-attenuated viruses, inactivated organisms, or protein subcomponents via different routes. In the context of protein immunization, we demonstrate that Tcf1 and Lef1 transcription factors play critical roles in suppressing excessive induction of CTLA4 and LAG3 coinhibitory receptors in T FH cells and, hence, preventing undue inhibition of B cells. This function is in contrast to the requirement for Tcf1 and Lef1 in induction of Bcl6 in T FH cells elicited by viral or bacterial infections. These findings highlight that the same protein factors could be utilized to regulate distinct aspects of T FH cell differentiation depending on vaccination routes and regimens.
Authors: Fengyin Li, Xin Zhao, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, Hai-Hui Xue
Institutions: University of Science and Technology of China, Chinese Academy of Sciences, Hackensack University Medical Center, Roswell Park Comprehensive Cancer Center, University of Iowa, Xidian University, National Institutes of Health, National Heart, Lung, and Blood Institute, VA New Jersey Health Care System, East Orange VA Medical Center
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3114133415