Diet alters age-related remodeling of aortic collagen in mice susceptible to atherosclerosis
Year: 2020
Type: article
Abstract: The following major observations were made in this study: 1) aortic adventitial collagen fibers become more longitudinally oriented with aging in apolipoprotein E knockout mice fed a chow diet; 2) conversely, adventitial collagen fibers become more circumferentially oriented with aging in apoE knockout mice fed a high-fat diet; 3) adventitial collagen content increases significantly with age in mice on a high-fat diet; 4) these alterations in collagen organization occur largely in the absence of hemodynamic changes; and 5) circumferential reorientation of collagen is associated with decreased active force generation (contractility) in aged mice on a high-fat diet.
Institutions: University of South Carolina, Bentley University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: G2852059213, Pilot Study of Gender-specific Differences in Failure Resistance and Material Fatigue of Human Carotid Atherosclerotic Plaques, G5208732180, G5265429791, G6473874366, G7108632907, G7128939583, NATIONAL BIOMEDICAL COMPUTATION RESOURCE, Medial Arterial Calcification: Mechanisms and Therapy, G8580025780, Targeted therapy to reverse aortic aneurysms
OpenAlex ID: W3114760920