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Lipid metabolism and cancer

Year: 2020
Type: review
Abstract: Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological membranes, and signaling molecules needed for proliferation, survival, invasion, metastasis, and response to the tumor microenvironment impact and cancer therapy. Here, we summarize and discuss current knowledge about the advances made in understanding the regulation of lipid metabolism in cancer cells and introduce different approaches that have been clinically used to disrupt lipid metabolism in cancer therapy.
DOI: 10.1084/jem.20201606
Authors: Xueli Bian, Rui Liu, Ying Meng, Dongming Xing, Daqian Xu, Zhimin Lu
Institutions: Qingdao University, Affiliated Hospital of Qingdao University, Chinese Academy of Medical Sciences & Peking Union Medical College, Sichuan University, State Key Laboratory of Oral Diseases, First Affiliated Hospital Zhejiang University, Zhejiang University, Tsinghua University
Language: English
Subfield: Cancer Research
Open Access status: hybrid
OpenAlex ID: W3114796419
FWCI: 7.377
Cites: 207
Cited by: 1,060
Related to: 10