Predictors of pain response after endoscopic ultrasound-guided celiac plexus neurolysis for abdominal pain caused by pancreatic malignancy
Year: 2020
Type: article
Study design: Observational Study
Abstract: BACKGROUNDEndoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) has gained popularity as a minimally invasive approach and is currently widely used to treat pancreatic cancer-associated pain.However, response to treatment is variable. AIMTo identify the efficacy of EUS-CPN and explore determinants of pain response in EUS-CPN for pancreatic cancer-associated pain. METHODSA retrospective study of 58 patients with abdominal pain due to inoperable pancreatic cancer who underwent EUS-CPN were included.The efficacy for palliation of pain was evaluated based on the visual analog scale pain score at 1 wk and 4 wk after EUS-CPN.Univariable and multivariable logistic regression analyses were performed to explore predictors of pain response. RESULTSA good pain response was obtained in 74.1% and 67.2% of patients at 1 wk and 4 wk, respectively.Tumors located in the body/tail of the pancreas and patients receiving bilateral treatment were weakly associated with a good outcome.Multivariate analysis revealed patients with invisible ganglia and metastatic disease were significant factors for a negative response to EUS-CPN at 1 wk and 4 wk, respectively, particularly for invasion of the celiac plexus (odds ratio (OR) = 13.20,P = 0.003 for 1 wk and OR = 15.11,P = 0.001 for 4 wk).No severe adverse events were reported. Han CQ et al. Predictors of pain response by EUS-CPN
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W3114834841