Work

H‐MAGMA, inheriting a shaky statistical foundation, yields excess false positives

Year: 2020

Type: article

Abstract: The ‘snp-wise mean model’ of Multi-marker Analysis of GenoMic Annotation is often used to perform gene-level testing for association with disease and other phenotypes. This methodology, in turn, forms the foundation for H-MAGMA. Unfortunately, that foundation is unsound, with implications for H-MAGMA results published in Nature Neuroscience regarding genes associated with psychiatric disorders: e.g., only 125 of H-MAGMA’s 275 reported discoveries for autism replicate when the foundation’s flaws are corrected.

Source: Annals of Human Genetics

DOI: 10.1111/ahg.12412

Authors: Ronald Yurko, Kathryn Roeder, Bernie Devlin, Max G’Sell

Institutions: Carnegie Mellon University, University of Pittsburgh

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, Simons Foundation, Simons Foundation Autism Research Initiative, National Institute of Mental Health