Bacillibactins E and F from a Marine Sponge-Associated Bacillus sp.
Year: 2020
Type: article
Abstract: Chemical investigation of a marine sponge-associated Bacillus sp. led to the discovery of bacillibactins E and F ( 1 and 2 ). Despite containing the well-established cyclic triester core of iron-binding natural products such as enterobactin, bacillibactins E and F ( 1 and 2 ) are the first bacterial siderophores that contain nicotinic and benzoic acid moieties. The structures of the new compounds, including their absolute configurations, were determined by extensive spectroscopic analyses and Marfey’s method. A plausible biosynthetic pathway to 1 and 2 is proposed; this route bears great similarity to other previously established bacillibactin-like pathways but appears to differentiate itself by a promiscuous DhbE, which likely installs the nicotinic moiety of 1 and the benzoic acid group of 2 .
Source: Journal of Natural Products
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Agriculture, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, Office of Integrative Activities, Division of Molecular and Cellular Biosciences, Division of Biological Infrastructure, National Center for Advancing Translational Sciences, National Center for Complementary and Integrative Health
Awards: WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISON, Upgrade of the NMRFAM 750 MHz NMR Spectrometer, G327276892, National Biomedical NMR Resource at Madison, Integrated state-of-the-art LC-MS/NMR system for the University of Wisconsin, Antimicrobial Drug Discovery from Coevolved Symbiotic Communities, G5026239335, G5268575721, National Biomedical NMR Resource at Madison, CONSOLE UPGRADES FOR NMR FACILITY, NMR Spectrometer System Optimized for Direct 13C or 15N Detection, G6098347204, G6365584381, Novel antimicrobials targeting MDR pathogens from animal microbial symbionts, Chemical biology of bacterial symbionts, G8833305062
OpenAlex ID: W3115593871