Work

TRPC6 Depletion Results in Loss of Myocardin and Phenotypic Modulation in Vascular Smooth Muscle Cells

Year: 2020

Type: article

Abstract: The contractile phenotype of vascular smooth muscle cells (VSMC) is regulated by expression of the master transcription factor, myocardin. Loss of myocardin is observed during VSMC phenotypic switching and within the hyperplastic neointima after vascular intervention. We have shown that depletion of the nonvoltage gated calcium-permeable channel, canonical transient receptor potential 6 (TRPC6) channel, promotes VSMC phenotypic modulation and more severe carotid stenosis following wire injury. The goal of this study was to determine if TRPC6 regulates VSMC phenotype by altering expression of myocardin.

Source: JVS Vascular Science

DOI: 10.1016/j.jvssci.2020.11.005

Authors: Andrew H. Smith, Priya Putta, Erin Driscoll, Pinaki Chaudhuri, Michael Rosenbaum, Linda M. Graham

Institutions: Cleveland Clinic, Louis Stokes Cleveland VA Medical Center

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800