Effects of injectable platelet rich fibrin on bone remodeling in combination with DBBM in maxillary sinus elevation: a randomized preclinical study.
Year: 2020
Type: article
Abstract: OBJECTIVES: This study aims to assess the angiogenic and osteogenic capacity in rabbit sinus model grafted with Deproteinized bovine bone mineral (DBBM) particles soaked in injectable Platelet rich fibrin (iPRF), both of which interacted to form an integrated block. MATERIALS AND METHODS: Among sixteen rabbits, bilateral maxillary sinuses were randomly grafted with either DBBM containing iPRF (iPRF+DBBM group), or DBBM alone (DBBM group). After a 4 and 8-week healing period, animals were sacrificed for micro-CT, histological and immunofluorescence analyses, respectively. RESULTS: week. Moreover, the substitution rate of DBBM by new bone formation after 8 weeks was significantly higher in the experimental group. As a result, mature collagen fibers were detected in the larger amount of area in iPRF+DBBM group even at an early stage. CONCLUSION: iPRF+DBBM accelerated vascular formation, bone remodeling and substitution of bone graft materials at the early healing period, even though it failed to increase the bone volume in a long-term period. This integrated grafting biomaterial will have great potential in the application of sinus augmentation, which provides a favorable environment for early implant placement.
Source: PubMed
Authors: Zhixiang Mu, Qingqing He, Liangjing Xin, Yihan Li, Shuai Yuan, Huawei Zou, Linjing Shu, Jinlin Song, Yuanding Huang, Tao Chen
Language: English
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3116848122