Discovery of Fifteen New Aging-Delaying Plant Extracts That Extend the Longevity of Budding Yeast and Make Yeast Cells More Resistant to Long-Term Oxidative and Thermal Stresses.
Year: 2020
Type: dissertation
Abstract: In a quest for previously unknown aging-delaying (geroprotective) natural chemicals, we used a robust cell viability assay to conduct a screen of a library of commercially available plant extracts. Our screen was aimed at the identification of those plant extracts in the library that can significantly prolong the chronological lifespan of budding yeast. Many of the plant extracts in the library have been used in traditional Chinese and other herbal medicines or the Mediterranean and other customary diets. The screen allowed us to discover fifteen plant extracts that considerably extend the longevity of chronologically aging budding yeast not limited in calorie supply. We demonstrated that each of the fifteen longevity-extending plant extracts is a geroprotector that decreases both the extrinsic and the intrinsic rates of aging in budding yeast. Our findings provided evidence that each of the fifteen longevity-extending plant extracts makes yeast more resistant to chronic (long-term) oxidative and thermal stresses. We also revealed that each of the fifteen geroprotective plant extracts mimics the longevity-extending and stressprotecting effects of a caloric restriction diet in yeast cells that are not limited in calorie supply and age chronologically.
Authors: Lozano Rodriguez, Monica Enith
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3117714504