Work

Use of pegylated interferon in young patients with polycythemia vera and essential thrombocythemia

Year: 2020

Type: article

Study design: Observational Study

Abstract: Myeloproliferative neoplasms (MPN) are rare disorders in young patients, and because of this, standardized treatment recommendations are not available. Pediatric patients are more frequently treated with hydroxyurea than interferon, yet there are no data suggesting this is the best practice. Current treatment guidelines for adults suggest using interferon as upfront therapy in young patients. We reviewed the cases of 13 young patients with polycythemia vera or essential thrombocythemia, who were treated with interferon. Extreme thrombocytosis was well controlled and the medication was tolerated by many. Our work shows the need for prospective studies evaluating interferon in our youngest patients with MPN.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.28888

Authors: Nicole Kucine, Shayla Bergmann, Spencer Krichevsky, Devin Jones, Michael Rytting, Juhi Jain, Carolyn M. Bennett, Linda M.S. Resar, John Mascarenhas, Srdan Verstovsek, Ronald Hoffman

Institutions: Weill Cornell Medicine, Medical University of South Carolina, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Emory University, Children's Healthcare of Atlanta, Johns Hopkins University, Johns Hopkins Medicine, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Myeloproliferative Neoplasms: Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: HMGA Chromatin Remodeling Proteins in Tumor Progression in Myeloproliferative Neoplasms (MPN), The HMGA1 Chromatin Regulator in Hematopoietic Stem Cells with Aging, Clinical and Translational Science Center, Pathogenesis and Symptomatology of Pediatric Myeloproliferative Neoplasms, Myeloproliferative Neoplasms-Research Consortium, Clinical and Translational Science Center

OpenAlex ID: W3117992776

FWCI: 1.036

Cites: 17

Cited by: 14

Related to: 10