Consensus Statement for Pharmacological Management of Coronavirus Disease 2019 (COVID-19): A Pragmatic Approach
Year: 2020
Type: article
Abstract: Introduction: In the absence of high-quality evidence for Coronavirus disease-2019 (COVID-19), supportive care is advocated during this pandemic. We aim to develop a consensus statement from global experts for pharmacological management, based on the pathophysiology of COVID-19. Material and Methods: We used a modified Delphi methodology in three steps: 1) Formulation of the steering committee and questionnaire; 2) Delphi methodology and selection of experts; 3) Final meeting of the steering committee and analysis, discussion, preparation, and presentation of captured data. Results: 34 (73·9%) experts accepted the invitation for the study. We conducted two rounds of Delphi and consensus (>70% votes) was achieved on 11 out of 24 statements after the end of round two. Conclusion: This global consensus suggests that “Anti-viral therapy should be administered in the early infection phase of COVID-19 followed by low dose steroid therapy in pulmonary phase. Prophylactic dose anticoagulation should be used in hospitalized, mild to moderate COVID-19 patients. We make no suggestions for the use of immune modulation therapy”.
Authors: Jain R, Javeri Y, Nasa P, Kashyap R, Khanna AK, Tayar AA, Bhaskar B, Jagiasi BG, Juneja D, Lipman J, Ng J, Portilla JLP, Zirpe K, Popugaev KA, Hashmi M, Malbrain MLNG, Kirkman MA, Chan MTV, Turkoglu M, Mer M, Singer M, Harriss M, Rangappa P, Piacevoli Q, Mani RK, Mishra RC, Garg R, Yadav R, Bagdia S, Donovan S, Reza ST, Yeh TY, Videtta W
Institutions: Mayo Clinic, Wake Forest University, Security Forces Hospital, Dubai Hospital, Max Super Speciality Hospital, The University of Queensland, Université de Montpellier, Tan Tock Seng Hospital, EsSALUD, Hospital Almanzor Aguinaga Asenjo, Ruby Hall Clinic, N.V. Sklifosovsky Research Institute of Emergency Medicine, Ziauddin University, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, St George's Hospital, Chinese University of Hong Kong, Gazi University, University of the Witwatersrand, University College London, Columbia Asia, Università Campus Bio-Medico, Ss. Cyril and Methodius University in Skopje, Yashoda Hospital, All India Institute of Medical Sciences, Dubai Health Authority, University of California, Los Angeles, Dhaka Medical College and Hospital, National Taiwan University Hospital, Hospital Posadas
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Israel Science Foundation
OpenAlex ID: W3118153451