Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis
Year: 2021
Type: article
Study design: Case Report
Abstract: Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases. Here, we report a case that multiple anti-neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adenocarcinoma. Furthermore, the immunopathological investigation of the colorectal adenocarcinoma revealed the formation of abnormal neuronal antigens and a massive infiltration of plasma cells in the tumor tissue. These findings support the hypothesis that expression of neuronal antigens in neoplasm initiates autoimmune responses in PAE.
DOI: 10.1002/acn3.51283
Authors: Yaqing Shu, Dan He, Xiaoyu Ma, Jianfang Li, Haotian Wu, Chen Chen, Zhengqi Lu, Frank Petersen, Wei Qiu, Xinhua Yu
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,300
Awards: G22731876, G2506673267, G8295567986
OpenAlex ID: W3118384970