Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD
Year: 2021
Type: article
Abstract: Background Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. Methods and Results We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF ( n = 3158), those with incident AF ( n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. Conclusion In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.
Source: Kidney International Reports
Authors: Mark D. McCauley, Jesse Y. Hsu, Ana C. Ricardo, Dawood Darbar, Mayank Kansal, Manjula Kurella Tamura, Harold I. Feldman, John W. Kusek, Jonathan J. Taliercio, Panduranga S. Rao, Tariq Shafi, Jiang He, Xue Wang, Daohang Sha, Melissa Lamar, Alan S. Go, Kristine Yaffe, James P. Lash, Lawrence J. Appel, Mahboob Rahman, Raymond R. Townsend
Institutions: University of Illinois Chicago, Jesse Brown VA Medical Center, University of Pennsylvania, Stanford University, Cleveland Clinic, University of Michigan, University of Mississippi Medical Center, University of Mississippi, Tulane University, Rush University, Kaiser Permanente, University of California, San Francisco, Kaiser Permanente Northern California
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,625
Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1060671437, G1201304535, Clinical and Translational Science Institute, G1815451664, Hispanic Chronic Renal Insufficiency Cohort(CRIC) Study, Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study, Training Program in Personalized Cardiovascular Medicine (TPIPCVM), General Clinical Research Center, G3977087618, G4401732512, G5837632770, G5931204509, Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dish, Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial Fibrillation, Deciphering the genetic mechanisms of atrial fibrillation, Institute for Clinical and Translational Research, G7628335921, Institutional Clinical and Translational Science Award, PPP1R12C contributes to myosin light chain de-phosphorylation and atrial hypocontractility in atrial fibrillation, Health Disparities in Chronic Kidney Disease Mentoring Program, Clinical and Translational Science Collaborative of Cleveland, Clinical and Translational Science Collaborative of Cleveland, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases, A pilot trial of an intervention to support initial type 2 diabetes selfmanagement among younger adults with children., Prospective renal insufficiency cohort evaluation: PRICE, Continuation of the Chronic Renal Insufficiency Cohort (CRIC), Continuation of the University of Illinois Chicago CRIC Clinical Center, Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center, Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study, Chronic Renal Insufficiency Cohort Limited competition continuation, Chronic Renal Insufficiency Cohort (CRIC) Study, G992700738
OpenAlex ID: W3118601435