Year: 2006
Type: conference-paper
Abstract: This paper presents the world's first in-channel parylene dualvalved microfluidic system for unpowered microflow regulation.Incorporating a normally-closed and a normally-open passive check valve in a back-to-back configuration inside a microchannel, the dual-valved system has successfully regulated the pressure/flow rate of air or liquid without power consumption or electronic/magnetic/thermal transduction.By exclusively using parylene C as the structural material, the fabricated valves have higher flexibility to shunt flows in comparison with other conventional thin-film valves.In addition, the parylene-based devices are completely biocompatible/implantable, and provide an economical paradigm for fluidic control in integrated lab-on-a-chip systems.Testing results have successfully demonstrated that the microflow regulation of the dual-valved system can achieve mmHg pressure -mL/min flow rates for air and mmHg pressure -µL/min flow rates for water.This regulation range is suitable for controlling biological conditions in human healthcare, such as regulating elevated intraocular pressure (IOP) in glaucoma patients.
Authors: P.-J. Chen, D.C. Rodger, E. Meng, M.S. Humayun, Y.-C. Tai
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Funder: National Science Foundation
OpenAlex ID: W3118724945