Work

Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic Escherichia coli CFT073

Year: 2021

Type: article

Abstract: Siderophore-β-lactam conjugates based on enterobactin and diglucosylated enterobactin enter the periplasm of uropathogenic E. coli CFT073 via the FepA and IroN transporters, and target penicillin-binding proteins.

Source: Chemical Science

DOI: 10.1039/d0sc04337k

Authors: Artur Sargun, Timothy C. Johnstone, Hui Zhi, Manuela Raffatellu, Elizabeth M. Nolan

Institutions: Massachusetts Institute of Technology, University of California San Diego, Chiba University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Burroughs Wellcome Fund, Chiba University, National Institutes of Health, University of California, San Diego, National Institute of Allergy and Infectious Diseases, National Institute of Environmental Health Sciences

Awards: Siderophore-based antibiotics: consequences for the microbiota and bacterial pathogens, Development of siderophore-based vaccines against non-typhoidal Salmonella infection, MIT Center for Environmental Health Sciences, G4056874268, Harnessing iron acquisition to hinder enterobacterial pathogenesis, C3-Dependent Intracellular Killing in Innate Immunity and Bacterial Pathogenesis, Nutritional immunity during Salmonella infection, G9000265053, G9000279344, Nutritional immunity during Salmonella infection

OpenAlex ID: W3118819046

FWCI: 2.699

Cites: 109

Cited by: 33

Related to: 10