Mdm2 is not required for the p53-independent roll of MdmX in genome stability and cell transformation in vitro
Year: 2012
Type: article
Abstract: The purpose of this project was to determine whether protein Mdm2, a p53 regulator previously shown to interact with MdmX, is required for the p53-independent role of MdmX in genome stabilization and suppression of cell transformation in vitro. Triple knock-out (TKO) cells lacking p53, Mdm2, and MdmX were transfected with an MdmX expression plasmid. Compared to control cells, TKO cells ectopically expressing MdmX show decreased cell proliferation, a longer cell cycle, increased chromosome numbers and bipolar mitotic spindles, and decreased foci formation. Thus, MdmX, even in the absence of Mdm2, plays a role in genome stability and proliferation. This is crucial to consider in regards to potential cancer treatments aimed to suppress Mdm2 and/or MdmX in order to reactivate p53.
Source: Digital WPI
Author: Anika Jeanette Blodgett
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3118933548