Year: 2020
Type: article
Study design: Observational Study
Abstract: Purpose: Proton pump inhibitors (PPIs) are widely used in intensive care units (ICU).Adverse events such as acute interstitial nephritis, acute kidney injury and progression in chronic kidney disease have been frequently reported due to the use of PPIs.The purpose of this study is to evaluate the effects of pantoprazole, a PPI derivative, on renal functions. Materials and methods:The study was conducted by retrospectively analyzing the data of 60 patients aged 24-89, who were admitted to the ICU, examined and treated.The patients participated in the study were divided into two groups as Group A (n=36; pantoprazole group) and Group B (n=24; control group).The study included patients who had normal renal function tests when admitted to the ICU, who were not in the risk group for kidney diseases, whose complete urinalysis, spot urine protein/creatinine ratio (PCr) and serum creatinine levels were studied during admission to and discharge from the unit, and who were hospitalized in the ICU for at least 48 hours.The urine output, spot urine protein/ creatinine ratios (PCr), serum creatinine level (sCr), estimated glomerular filtration rate of the patients were evaluated at admission and discharge from the ICU. Results:The study was conducted with 60.0% participation of Group A and 40.0%participation of Group B. The mean age of the patients was 59.18±17.77years, the length of ICU stay was 6.75±10.81days, and there was no significant difference between the intragroup urine outlet values; however, the amount of urine output was significantly higher in the control group and there was a statistically significant difference (p<0.001).There was no statistically significant difference between urine PCr values by groups both at intensive care admission and discharge (p=0.35,p=0.421).Compared to the control group, the increase in discharge spot urine PCr of the pantoprazole group was statistically significantly higher than the admission spot urine PCr (p=0.594,p=0.048).There was no statistically significant difference in all parameters of sCR within and between the groups (p>0.05). Conclusion:PPIs are not completely free of adverse effects, as noted by some practitioners.As demonstrated in the present study, the use of pantoprazole may be associated with isolated proteinuria.Therefore, the renal profile of patients should be closely monitored to prevent undesired renal complications.
Author: Ahmet Akyol
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W3119096187