Work

Research progress on the role of CaMKII in heart disease.

Year: 2020

Type: article

Abstract: related physiological activities, CaMKII is a key downstream regulator, involving autophosphorylation and post-translational modification, and plays an important role in the excitation contraction coupling and relaxation events of cardiomyocytes. This paper reviews the relationship between CaMKII and various substances in the pathological process of myocardial apoptosis and necrosis, myocardial hypertrophy and arrhythmia, and what roles it plays in the development of disease in complex networks. This paper also introduces the drugs targeting at CaMKII to treat heart disease.

Source: Europe PMC (PubMed Central)

Authors: Shi-Jun Jiang, Wei Wang

Institutions: Huazhong University of Science and Technology, Hubei University of Medicine, Taihe Hospital

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3119438004

FWCI: 0.972

Cites: 134

Cited by: 9

Related to: 10