Do ARX-3 and CSN-5 Protein Subunits Interact with MIG-10 to Promote Axon Outgrowth and Neuronal Migration in C. elegans?
Year: 2012
Type: article
Abstract: During nervous system development, the cytoplasmic signaling protein MIG-10 activates cellular processes in response to guidance cues which ultimately lead to axonal growth and migration. Interactions between MIG-10 and two candidate downstream proteins, CSN-5 and ARX-3, were studied in vivo, using mutant transgenic C. elegans strains, and in vitro, using a co-immunoprecipitation system. Preliminary results indicate interaction in vitro between MIG-10 and both proteins. In vivo experiments are ongoing.
Source: Digital WPI
Author: Meagan E. Sullender
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3119544317