Work

Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

Year: 2021

Type: article

Abstract: Gastrointestinal (GI) cancers are one of the most common malignancies worldwide, with high rates of morbidity and mortality. Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment (TME). MDSCs facilitate the transformation of premalignant cells and play roles in tumor growth and metastasis. Moreover, in patients with GI malignancies, MDSCs can lead to the suppression of T cells and natural killer cells. Accordingly, a better understanding of the role and mechanism of action of MDSCs in the TME will aid in the development of novel immune-targeted therapies.

Source: World Journal of Gastrointestinal Oncology

DOI: 10.4251/wjgo.v13.i1.1

Authors: Maham Farshidpour, Monjur Ahmed, Shilpa Junna, Juanita L Merchant

Institutions: Thomas Jefferson University, Banner - University Medical Center Tucson

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Institute of Diabetes and Digestive and Kidney Diseases