Year: 2021
Type: article
Abstract: This study was aimed to evaluate the administration effects of kratom leaves extracts on the liver of mice (Mus musculus).The total of 25 mice was divided into five groups, respectively; (A) without treatment, (B) treatment with distilled water at 0.50 ml/20 g body weight, (C) treatment of kratom leaves extracts with a dosage of 0.15 mg/20 g body weight, (D) treatment of kratom leaves extracts with a dosage to 0.30 mg/20 g body weight and (E) treatment with a dosage of silymarin at 0.70 mg/20 g body weight.All those treatments were completed in seven consecutive days.On day 8, blood withdrawal and liver dissection were executed.The average levels of AST enzyme in the treatment groups respectively showed 22.81 U/L (A), 23.30U/L (B), 34.86 U/L (C), 40.68 U/L (D), and 25.44 U/L (E), (p<0.05).Whereas, the average levels of ALT exposed respectively at 17.96 U/L (A), 18.35 U/L (B), 29.13 U/L (C), 33.59 U/L (D), and 20.68 U/L (E), (p<0.05).The average scoring for the treatment groups resulted in 0.33, 0.67, 1.33, 1.67, and 0.67, respectively, with p<0.05.Hence, it was concluded that the higher doses of the extracts of kratom leaves administered during the treatment, the more severe damage the liver organ became.
Source: Pharmacognosy Journal
Institution: Tanjungpura University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3119986941