Work

Systematic Study of Reaction Conditions for Size-Controlled Synthesis of Silica Nanoparticles

Year: 2024

Type: article

Abstract: This study presents a reproducible and scalable method for synthesizing silica nanoparticles (SNPs) with controlled sizes below 200 nm, achieved by systematically varying three key reaction parameters: ammonium hydroxide concentration, water concentration, and temperature. SNPs with high monodispersity and controlled dimensions were produced by optimizing these factors. The results indicated a direct correlation between ammonium hydroxide concentration and particle size, while higher temperatures resulted in smaller particles with increased polydispersity. Water concentration also influenced particle size, with a quadratic relationship observed. This method provides a robust approach for tailoring SNP sizes, with significant implications for biomedical applications, particularly in drug delivery and diagnostics. Using eco-friendly solvents such as ethanol further enhances the sustainability and cost-effectiveness of the process.

Source: Nanomaterials

DOI: 10.3390/nano14191561

Authors: Barbara Vörös-Horváth, Ala’ Salem, Barna Kovács, Aleksandar Széchenyi*, Szilárd Pál

Institutions: Egis Pharmaceuticals (Hungary), University of Pecs, Kingston University London

Language: English

Topic: Chemical and Physical Properties of Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,296

Funders: European Commission, Pécsi Tudományegyetem