The biology, function, and applications of exosomes in cancer
Year: 2021
Type: review
Abstract: Exosomes are cell-derived nanovesicles with diameters from 30 to 150 nm, released upon fusion of multivesicular bodies with the cell surface. They can transport nucleic acids, proteins, and lipids for intercellular communication and activate signaling pathways in target cells. In cancers, exosomes may participate in growth and metastasis of tumors by regulating the immune response, blocking the epithelial-mesenchymal transition, and promoting angiogenesis. They are also involved in the development of resistance to chemotherapeutic drugs. Exosomes in liquid biopsies can be used as non-invasive biomarkers for early detection and diagnosis of cancers. Because of their amphipathic structure, exosomes are natural drug delivery vehicles for cancer therapy.
Source: Acta Pharmaceutica Sinica B
Authors: Jinyi Liu, Liwen Ren, Sha Li, Wan Li, Xiangjin Zheng, Yihui Yang, Weiqi Fu, Jie Yi, Jinhua Wang, Guanhua Du
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,600
OpenAlex ID: W3120884777