Work

Two‐stage genome‐wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk

Year: 2021

Type: article

Abstract: Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk Int Forum Allergy Rhinol-C hronic rhinosinusitis (CRS) is a prevalent inflamma- tory disease that results in over $10 billion in healthcare costs annually in the United States.CRS (and its most severe form, nasal polyposis [NP]) overlaps clinically with asthma and aspirin-exacerbated respiratory disease (AERD).Despite having an enormous public health impact, the underlying molecular mechanisms of CRS remain unknown.That CRS has a genetic component is suggested by familial aggregation and co-occurrence with both monogenic (eg, cystic fibrosis, primary ciliary dyskinesia) and complex (eg, asthma, allergic rhinitis) genetic disorders.Recently, Kristjansson et al reported their large meta-analysis

Source: International Forum of Allergy & Rhinology

DOI: 10.1002/alr.22731