Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats
Year: 2021
Type: article
Abstract: in a "nose only" inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all.
DOI: 10.3390/ijms22010416
Authors: Boris A. Katsnelson, Ivan N. Chernyshov, Svetlana N. Solovyeva, Ilzira A. Minigalieva, Vladimir B. Gurvich, Irene E. Valamina, Oleg H. Makeyev, Renata R. Sahautdinova, Larisa I. Privalova, Anastasia E. Tsaregorodtseva, Artem V. Korotkov, Eugene A. Shuman, Vladimir G. Panov, Marina P. Sutunkova
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,160
OpenAlex ID: W3120924252