Work

Complement as a Therapeutic Target in Systemic Autoimmune Diseases

Year: 2021

Type: article

Abstract: The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.

Source: Cells

DOI: 10.3390/cells10010148

Authors: María Galindo-Izquierdo, José Luis Pablos Alvarez

Institutions: Universidad Complutense de Madrid, Research Institute Hospital 12 de Octubre

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,160